OncoDB.HCC Expression View

Gene name : LAP3
Ensembl ID ENSG00000002549
Description Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) (Peptidase S). [Source:Uniprot/SWISSPROT;Acc:P28838]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
23 percent with 2 folds change ( 0 up and 13 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 4 from 12187913 bp to 22218692 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 141623 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.08) HK1 (0.89) HK3 (-0.89) HK4 (-0.15) HK5 (0.82) HK7 (-1.55) HK9 (-1.31) HK11 (-0.59) HK12 (-0.56) HK13 (-1.88) HK14 (-2.00) HK15 (0.17) HK16 (0.88) HK18 (-0.62) HK19 (-0.97) HK20 (-0.60) HK21 (-0.37) HK22 (-0.90) HK24 (0.03) HK27 (0.63) HK28 (0.01) HK29 (-1.19) HK31 (-1.56) HK33 (0.60) HK36 (-1.09) HK37 (0.13) HK38 (-0.23) HK39 (-0.23) HK42 (-2.28) HK46 (0.02) HK47 (0.56) HK49 (-0.47) HK62 (-0.44) HK63 (-0.75) HK64 (-0.88) HK67 (-0.43) HK84 (0.00) HK85 (-1.69) SF1 (-0.34) SF12 (-1.11) SF15 (-0.26) SF17 (-0.34) SF18 (-1.76) SF21 (0.14) SF22 (-1.03) SF23 (0.71) SF32 (-0.47) SF34 (-0.83) SF35 (-0.77) SF3 (-1.11) SF30 (-0.51) HK2 (-0.68) HK23 (-0.18) HK41 (-0.37) SF4 (0.14) SF8 (-0.14) SF9 (0.33)