OncoDB.HCC Expression View

Gene name : CCL3
Ensembl ID ENSG00000006075
Description Small inducible cytokine A3 precursor (CCL3) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (Tonsillar lymphocyte LD78 alpha protein) (G0/G1 switch regulatory protein 19-1) (G0S19-1 protein) (SIS-beta) (PAT 464.1) [Contains: MIP-1-alpha(4-69) (LD [Source:Uniprot/SWISSPROT;Acc:P10147]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
74 percent with 2 folds change ( 4 up and 33 down in 50 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 17 from 26439737 bp to 36441517 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 460398 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-2.90) HK3 (-1.52) HK4 (-1.86) HK5 (-0.46) HK7 (0.00) HK9 (0.00) HK11 (-0.97) HK12 (-0.11) HK13 (-3.21) HK14 (-2.02) HK15 (-3.42) HK16 (-0.41) HK18 (0.30) HK19 (-1.23) HK20 (-1.23) HK21 (-0.34) HK22 (-0.66) HK24 (-1.68) HK27 (-1.44) HK28 (-3.04) HK29 (-0.64) HK31 (-1.40) HK33 (-0.93) HK36 (-2.81) HK37 (1.61) HK38 (-1.11) HK39 (-2.34) HK42 (-1.10) HK46 (-0.58) HK47 (2.56) HK49 (-2.78) HK62 (0.24) HK63 (0.00) HK64 (-2.99) HK67 (-1.45) HK84 (0.00) HK85 (1.67) SF1 (-2.09) SF12 (-3.49) SF15 (-2.05) SF17 (0.00) SF18 (-1.96) SF21 (-1.97) SF22 (0.00) SF23 (-3.27) SF32 (-1.78) SF34 (0.45) SF35 (-1.52) SF3 (-2.72) SF30 (-0.53) HK2 (-1.59) HK23 (-1.73) HK41 (1.44) SF4 (-1.82) SF8 (-1.79) SF9 (-1.14)