OncoDB.HCC Expression View

Gene name : NME1
Ensembl ID ENSG00000011052
Description Nucleoside diphosphate kinase B (EC 2.7.4.6) (NDK B) (NDP kinase B) (nm23-H2) (C-myc purine-binding transcription factor PUF). [Source:Uniprot/SWISSPROT;Acc:P22392]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
41 percent with 2 folds change ( 22 up and 1 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     cDNA microarray - - Shirota et al., Hepatology 33:832 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
up     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
up     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
up     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 17 from 41585919 bp to 51604103 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 845363 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.93) HK1 (1.94) HK3 (0.94) HK4 (1.55) HK5 (1.09) HK7 (-0.34) HK9 (0.00) HK11 (0.87) HK12 (0.31) HK13 (1.09) HK14 (1.55) HK15 (0.44) HK16 (0.09) HK18 (1.21) HK19 (0.15) HK20 (0.21) HK21 (0.78) HK22 (0.22) HK24 (1.59) HK27 (1.38) HK28 (2.57) HK29 (0.52) HK31 (0.66) HK33 (0.73) HK36 (2.03) HK37 (2.46) HK38 (1.00) HK39 (0.49) HK42 (0.67) HK46 (1.60) HK47 (1.59) HK49 (0.80) HK62 (-0.53) HK63 (0.03) HK64 (1.51) HK67 (0.97) HK84 (1.35) HK85 (-0.26) SF1 (0.07) SF12 (2.28) SF15 (0.91) SF17 (0.47) SF18 (0.64) SF21 (0.00) SF22 (0.90) SF23 (-0.49) SF32 (1.60) SF34 (-1.26) SF35 (0.68) SF3 (1.71) SF30 (1.59) HK2 (1.70) HK23 (-0.05) HK41 (2.03) SF4 (0.48) SF8 (0.63) SF9 (1.30)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).