OncoDB.HCC Expression View

Gene name : IGF1
Ensembl ID ENSG00000017427
Description Insulin-like growth factor IA precursor (IGF-IA) (Somatomedin C) (Mechano growth factor) (MGF). [Source:Uniprot/SWISSPROT;Acc:P01343]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
76 percent with 2 folds change ( 8 up and 34 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- EIA    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 12 from 96313809 bp to 106398471 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 502856 -- IMAGE clone locate on exon ( tblastx )
813179 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-1.91) HK3 (-2.46) HK4 (-5.32) HK5 (-0.46) HK7 (-0.05) HK9 (1.88) HK11 (-1.93) HK12 (-0.17) HK13 (-1.48) HK14 (-5.68) HK15 (-4.32) HK16 (0.13) HK18 (-2.34) HK19 (-1.13) HK20 (-2.26) HK21 (-3.02) HK22 (0.05) HK24 (-2.08) HK27 (-3.15) HK28 (-3.82) HK29 (-0.11) HK31 (0.49) HK33 (-0.17) HK36 (-1.76) HK37 (-4.21) HK38 (0.02) HK39 (-3.52) HK42 (-1.19) HK46 (-4.63) HK47 (-3.19) HK49 (-2.03) HK62 (-2.31) HK63 (-0.54) HK64 (-2.66) HK67 (-5.10) HK84 (1.15) HK85 (-2.90) SF1 (-1.00) SF12 (-4.80) SF15 (-3.04) SF17 (3.59) SF18 (-2.66) SF21 (1.10) SF22 (4.21) SF23 (1.62) SF32 (4.52) SF34 (-1.60) SF35 (-3.63) SF3 (-4.10) SF30 (-1.93) HK2 (0.00) HK23 (-2.17) HK41 (-0.59) SF4 (1.67) SF8 (-0.00) SF9 (-5.33)