OncoDB.HCC Expression View

Gene name : HGF
Ensembl ID ENSG00000019991
Description Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]. [Source:Uniprot/SWISSPROT;Acc:P14210]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
21 percent with 2 folds change ( 1 up and 11 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 7 from 76166258 bp to 86237388 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 41650 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.31) HK1 (-1.02) HK3 (-0.44) HK4 (-0.92) HK5 (-1.15) HK7 (-0.16) HK9 (-0.29) HK11 (-0.44) HK12 (-0.50) HK13 (-0.14) HK14 (0.80) HK15 (-0.48) HK16 (-0.65) HK18 (-1.31) HK19 (-1.47) HK20 (0.41) HK21 (-1.32) HK22 (0.26) HK24 (-0.80) HK27 (-1.16) HK28 (-0.70) HK29 (-0.52) HK31 (-0.91) HK33 (-0.84) HK36 (-0.56) HK37 (-0.35) HK38 (-0.73) HK39 (-1.12) HK42 (0.00) HK46 (-0.87) HK47 (-1.77) HK49 (-0.48) HK62 (-1.77) HK63 (0.07) HK64 (0.24) HK67 (0.41) HK84 (0.00) HK85 (-0.75) SF1 (-1.16) SF12 (-0.08) SF15 (0.18) SF17 (1.51) SF18 (-0.14) SF21 (0.18) SF22 (-0.14) SF23 (-0.11) SF32 (-0.25) SF34 (0.12) SF35 (-0.97) SF3 (-0.53) SF30 (0.72) HK2 (-0.45) HK23 (-0.25) HK41 (-1.06) SF4 (0.08) SF8 (-0.30) SF9 (-0.24)