OncoDB.HCC Expression View

Gene name : CPS1
Ensembl ID ENSG00000021826
Description Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I). [Source:Uniprot/SWISSPROT;Acc:P31327]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 10 up and 19 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
down     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 2 from 206050678 bp to 216252074 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 83605 -- IMAGE clone locate on exon ( tblastx )
292399 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.09) HK1 (-0.77) HK3 (-1.63) HK4 (-2.64) HK5 (2.99) HK7 (1.61) HK9 (-0.58) HK11 (-0.33) HK12 (-2.11) HK13 (0.61) HK14 (-0.39) HK15 (-1.53) HK16 (-0.09) HK18 (-1.46) HK19 (0.50) HK20 (-0.31) HK21 (-2.19) HK22 (0.76) HK24 (0.61) HK27 (-2.89) HK28 (-0.48) HK29 (0.70) HK31 (1.00) HK33 (-0.16) HK36 (0.06) HK37 (-5.01) HK38 (-0.02) HK39 (-3.15) HK42 (-1.84) HK46 (-0.75) HK47 (-1.80) HK49 (1.53) HK62 (0.15) HK63 (-0.64) HK64 (-0.37) HK67 (-1.23) HK84 (0.39) HK85 (0.74) SF1 (-0.91) SF12 (-1.30) SF15 (-0.12) SF17 (2.04) SF18 (-3.73) SF21 (0.78) SF22 (4.85) SF23 (-4.63) SF32 (2.42) SF34 (0.97) SF35 (-1.76) SF3 (-1.68) SF30 (-2.88) HK2 (-0.24) HK23 (-0.64) HK41 (1.64) SF4 (1.21) SF8 (-0.35) SF9 (-3.46)