OncoDB.HCC Expression View

Gene name : DEF6
Ensembl ID ENSG00000023892
Description differentially expressed in FDCP 6 homolog [Source:RefSeq_peptide;Acc:NP_071330]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
29 percent with 2 folds change ( 0 up and 17 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 6 from 30373607 bp to 40397526 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 753062 -- IMAGE clone locate on exon ( tblastx )
753110 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.08) HK1 (0.53) HK3 (-0.15) HK4 (-1.91) HK5 (-0.67) HK7 (-0.68) HK9 (-0.77) HK11 (-0.52) HK12 (-0.44) HK13 (-1.09) HK14 (-0.62) HK15 (-0.29) HK16 (-1.66) HK18 (-0.53) HK19 (-0.03) HK20 (-0.94) HK21 (-0.30) HK22 (-1.25) HK24 (-0.94) HK27 (-0.23) HK28 (-1.41) HK29 (-1.10) HK31 (-1.03) HK33 (-0.96) HK36 (-0.70) HK37 (-0.41) HK38 (-0.28) HK39 (-0.33) HK42 (-0.64) HK46 (-0.80) HK47 (0.19) HK49 (-0.27) HK62 (0.45) HK63 (0.15) HK64 (-1.43) HK67 (-0.90) HK84 (0.60) HK85 (-2.30) SF1 (-1.09) SF12 (-1.43) SF15 (-1.14) SF17 (-2.25) SF18 (-0.05) SF21 (0.55) SF22 (-0.26) SF23 (-0.48) SF32 (-1.21) SF34 (0.43) SF35 (-0.31) SF3 (-0.57) SF30 (-0.20) HK2 (-1.20) HK23 (-1.38) HK41 (-2.42) SF4 (0.10) SF8 (-0.21) SF9 (0.72)