OncoDB.HCC Expression View

Gene name : CD44
Ensembl ID ENSG00000026508
Description CD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I) (Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (Hermes antigen) (Hyaluronate receptor) (Heparan sulfate proteoglycan) (Epican) (CDw44). [Source:Uniprot/SWISSPROT;Acc:P16070]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
29 percent with 2 folds change ( 5 up and 12 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 11 from 30116993 bp to 40210522 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 328868 -- IMAGE clone locate on exon ( tblastx )
713145 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.92) HK1 (0.66) HK3 (0.38) HK4 (0.06) HK5 (0.94) HK7 (0.12) HK9 (-1.15) HK11 (0.46) HK12 (-0.99) HK13 (-0.40) HK14 (-0.24) HK15 (0.48) HK16 (0.73) HK18 (0.92) HK19 (-1.19) HK20 (-0.47) HK21 (0.45) HK22 (-0.79) HK24 (-1.66) HK27 (0.73) HK28 (-1.61) HK29 (-0.61) HK31 (-0.57) HK33 (-1.07) HK36 (-0.32) HK37 (-0.35) HK38 (0.04) HK39 (0.37) HK42 (-1.11) HK46 (-0.82) HK47 (-0.99) HK49 (0.88) HK62 (1.19) HK63 (-2.17) HK64 (-1.48) HK67 (-0.32) HK84 (-0.51) HK85 (-1.29) SF1 (-0.47) SF12 (1.22) SF15 (3.05) SF17 (-0.46) SF18 (2.83) SF21 (0.77) SF22 (-0.05) SF23 (-1.00) SF32 (-1.25) SF34 (-0.74) SF35 (0.28) SF3 (-0.94) SF30 (-0.70) HK2 (-1.50) HK23 (0.46) HK41 (-0.41) SF4 (-0.21) SF8 (1.67) SF9 (0.79)