OncoDB.HCC Expression View

Gene name : GRN
Ensembl ID ENSG00000030582
Description Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]. [Source:Uniprot/SWISSPROT;Acc:P28799]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
22 percent with 2 folds change ( 13 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 17 from 34778017 bp to 44785996 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 755762 -- IMAGE clone locate on exon ( tblastx )
782427 -- IMAGE clone locate on exon ( tblastx )
1861415 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.26) HK1 (0.11) HK3 (0.26) HK4 (0.76) HK5 (0.61) HK7 (0.97) HK9 (0.72) HK11 (0.62) HK12 (-0.49) HK13 (0.32) HK14 (1.62) HK15 (0.51) HK16 (1.06) HK18 (1.28) HK19 (0.43) HK20 (0.28) HK21 (0.80) HK22 (0.04) HK24 (0.45) HK27 (0.83) HK28 (0.62) HK29 (0.78) HK31 (0.56) HK33 (-0.05) HK36 (-0.84) HK37 (0.96) HK38 (0.71) HK39 (0.98) HK42 (1.14) HK46 (0.78) HK47 (-0.91) HK49 (0.28) HK62 (1.25) HK63 (0.26) HK64 (1.43) HK67 (0.11) HK84 (1.50) HK85 (-0.12) SF1 (1.22) SF12 (0.69) SF15 (-0.75) SF17 (-0.02) SF18 (1.29) SF21 (1.08) SF22 (0.60) SF23 (-0.29) SF32 (-0.04) SF34 (0.88) SF35 (2.07) SF3 (0.69) SF30 (2.03) HK2 (0.87) HK23 (0.53) HK41 (-0.32) SF4 (0.33) SF8 (0.68) SF9 (1.61)