OncoDB.HCC Expression View

Gene name : CDH1
Ensembl ID ENSG00000039068
Description Epithelial-cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1) (CAM 120/80) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E- Cad/CTF3]. [Source:Uniprot/SWISSPROT;Acc:P12830]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
54 percent with 2 folds change ( 8 up and 18 down in 48 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- IHC, Methylation    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 16 from 62328696 bp to 72426943 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 416386 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.57) HK1 (-2.03) HK3 (-1.77) HK4 (-4.53) HK5 (-2.62) HK7 (0.00) HK9 (1.01) HK11 (1.13) HK12 (-1.14) HK13 (-0.85) HK14 (-0.97) HK15 (-2.66) HK16 (-0.14) HK18 (-0.04) HK19 (-1.29) HK20 (-0.80) HK21 (2.27) HK22 (0.69) HK24 (0.46) HK27 (-1.48) HK28 (-1.99) HK29 (-0.37) HK31 (-0.71) HK33 (1.61) HK36 (-0.74) HK37 (-0.47) HK38 (-0.67) HK39 (0.55) HK42 (0.41) HK46 (0.00) HK47 (0.00) HK49 (0.00) HK62 (-0.94) HK63 (0.46) HK64 (0.97) HK67 (-1.19) HK84 (-1.16) HK85 (1.27) SF1 (0.97) SF12 (-1.55) SF15 (-3.47) SF17 (-2.76) SF18 (-0.46) SF21 (1.90) SF22 (0.92) SF23 (-3.30) SF32 (3.07) SF34 (1.59) SF35 (0.08) SF3 (-1.62) SF30 (0.00) HK2 (-0.36) HK23 (0.00) HK41 (-1.73) SF4 (0.00) SF8 (0.00) SF9 (0.00)