OncoDB.HCC Expression View

Gene name : OAT
Ensembl ID ENSG00000065154
Description Ornithine aminotransferase, mitochondrial precursor (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase) [Contains: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]. [Source:Uniprot/SWISSPROT;Acc:P04181]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
64 percent with 2 folds change ( 5 up and 29 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 10 from 121075866 bp to 131097495 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 783696 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.61) HK1 (-1.99) HK3 (-1.96) HK4 (-0.45) HK5 (-1.06) HK7 (-3.02) HK9 (-2.91) HK11 (0.00) HK12 (0.10) HK13 (-3.15) HK14 (-1.49) HK15 (-2.06) HK16 (0.09) HK18 (-3.28) HK19 (0.90) HK20 (-3.03) HK21 (-2.03) HK22 (0.03) HK24 (0.05) HK27 (-2.40) HK28 (-2.38) HK29 (-3.23) HK31 (-3.49) HK33 (-4.53) HK36 (-0.41) HK37 (-2.69) HK38 (-4.99) HK39 (-2.29) HK42 (0.48) HK46 (1.05) HK47 (-0.09) HK49 (0.00) HK62 (0.26) HK63 (-4.10) HK64 (-3.63) HK67 (1.70) HK84 (0.00) HK85 (0.53) SF1 (0.24) SF12 (-0.42) SF15 (1.82) SF17 (-2.52) SF18 (-5.37) SF21 (-0.37) SF22 (0.49) SF23 (0.67) SF32 (-3.42) SF34 (0.00) SF35 (-1.40) SF3 (0.91) SF30 (-2.93) HK2 (-7.74) HK23 (-2.58) HK41 (0.88) SF4 (3.22) SF8 (-0.11) SF9 (-1.14)