OncoDB.HCC Expression View

Gene name : ERBB3
Ensembl ID ENSG00000065361
Description Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3). [Source:Uniprot/SWISSPROT;Acc:P21860]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
14 percent with 2 folds change ( 1 up and 1 down in 14 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR,IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 12 from 49760159 bp to 59783395 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 267420 -- IMAGE clone locate on exon ( blastn )
CH2 (0.00) HK1 (0.00) HK3 (0.23) HK4 (0.43) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (-0.47) HK12 (-0.52) HK13 (0.00) HK14 (0.06) HK15 (0.16) HK16 (0.00) HK18 (0.00) HK19 (0.00) HK20 (0.00) HK21 (0.00) HK22 (-1.24) HK24 (-0.07) HK27 (0.00) HK28 (0.00) HK29 (0.00) HK31 (0.00) HK33 (0.00) HK36 (0.00) HK37 (0.00) HK38 (0.29) HK39 (0.78) HK42 (0.00) HK46 (0.00) HK47 (0.00) HK49 (0.00) HK62 (0.00) HK63 (0.00) HK64 (0.00) HK67 (0.00) HK84 (0.00) HK85 (0.00) SF1 (-0.29) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (1.49) SF34 (-0.33) SF35 (0.00) SF3 (0.00) SF30 (0.00) HK2 (0.00) HK23 (0.00) HK41 (0.00) SF4 (-0.18) SF8 (0.00) SF9 (0.00)