OncoDB.HCC Expression View

Gene name : FGFR3
Ensembl ID ENSG00000068078
Description Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Source:Uniprot/SWISSPROT;Acc:P22607]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
36 percent with 2 folds change ( 12 up and 9 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- QPCR, IHC    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 4 from 0 bp to 6780396 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 752631 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.11) HK1 (-1.11) HK3 (-1.51) HK4 (-1.24) HK5 (-0.29) HK7 (0.99) HK9 (-0.04) HK11 (0.92) HK12 (0.75) HK13 (0.24) HK14 (1.06) HK15 (1.19) HK16 (-1.79) HK18 (-0.65) HK19 (1.20) HK20 (-0.16) HK21 (1.14) HK22 (-0.44) HK24 (0.42) HK27 (-1.25) HK28 (-0.61) HK29 (0.19) HK31 (-2.18) HK33 (-0.26) HK36 (0.33) HK37 (1.03) HK38 (-0.04) HK39 (-0.30) HK42 (1.17) HK46 (0.49) HK47 (0.78) HK49 (-0.19) HK62 (-1.68) HK63 (0.36) HK64 (-0.42) HK67 (0.86) HK84 (0.55) HK85 (2.00) SF1 (1.22) SF12 (1.13) SF15 (0.22) SF17 (-0.46) SF18 (0.02) SF21 (-1.05) SF22 (1.07) SF23 (-0.06) SF32 (-0.68) SF34 (1.98) SF35 (-0.38) SF3 (0.00) SF30 (0.48) HK2 (0.51) HK23 (0.37) HK41 (-1.13) SF4 (0.64) SF8 (-0.25) SF9 (0.73)