OncoDB.HCC Expression View

Gene name : PABPC1
Ensembl ID ENSG00000070756
Description Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1). [Source:Uniprot/SWISSPROT;Acc:P11940]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
45 percent with 2 folds change ( 26 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 8 from 96784320 bp to 106804115 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1374442 -- IMAGE clone locate on exon ( blastn )
840940 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.24) HK1 (1.51) HK3 (1.95) HK4 (-0.28) HK5 (1.26) HK7 (-0.05) HK9 (0.45) HK11 (1.96) HK12 (0.22) HK13 (0.16) HK14 (1.38) HK15 (0.62) HK16 (-0.32) HK18 (2.39) HK19 (1.83) HK20 (-0.05) HK21 (1.69) HK22 (1.11) HK24 (1.56) HK27 (2.13) HK28 (0.61) HK29 (-0.06) HK31 (-0.05) HK33 (1.33) HK36 (1.07) HK37 (2.24) HK38 (0.97) HK39 (-0.05) HK42 (0.86) HK46 (1.04) HK47 (2.53) HK49 (0.88) HK62 (0.52) HK63 (0.32) HK64 (-0.11) HK67 (1.64) HK84 (1.65) HK85 (0.64) SF1 (1.45) SF12 (2.58) SF15 (0.54) SF17 (0.79) SF18 (3.03) SF21 (0.52) SF22 (1.70) SF23 (0.09) SF32 (0.04) SF34 (-0.14) SF35 (0.59) SF3 (0.61) SF30 (-0.97) HK2 (1.87) HK23 (0.02) HK41 (1.95) SF4 (0.39) SF8 (0.93) SF9 (2.04)