OncoDB.HCC Expression View

Gene name : SPP2
Ensembl ID ENSG00000072080
Description Secreted phosphoprotein 24 precursor (Spp-24) (Secreted phosphoprotein 2). [Source:Uniprot/SWISSPROT;Acc:Q13103]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
72 percent with 2 folds change ( 3 up and 28 down in 43 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Oligo Microarray - - Tackels-Horne et al., Cancer 92:395 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 2 from 229624062 bp to 239650517 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 247241 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.87) HK1 (-3.97) HK3 (-3.52) HK4 (-2.19) HK5 (0.00) HK7 (-0.88) HK9 (-2.18) HK11 (0.39) HK12 (-2.94) HK13 (-3.19) HK14 (-7.21) HK15 (-4.57) HK16 (-1.12) HK18 (0.00) HK19 (0.00) HK20 (-2.21) HK21 (-1.38) HK22 (-0.41) HK24 (0.86) HK27 (-7.16) HK28 (-0.85) HK29 (-0.40) HK31 (0.08) HK33 (-2.22) HK36 (-1.96) HK37 (-6.08) HK38 (0.00) HK39 (-6.14) HK42 (-2.59) HK46 (-2.03) HK47 (0.00) HK49 (-1.44) HK62 (0.21) HK63 (-1.68) HK64 (-2.42) HK67 (1.56) HK84 (0.00) HK85 (2.66) SF1 (0.00) SF12 (0.00) SF15 (0.00) SF17 (-0.06) SF18 (0.00) SF21 (0.08) SF22 (0.00) SF23 (-0.01) SF32 (-5.18) SF34 (0.00) SF35 (0.00) SF3 (-5.59) SF30 (0.00) HK2 (-1.37) HK23 (-2.06) HK41 (1.75) SF4 (-5.93) SF8 (-1.78) SF9 (-7.76)