OncoDB.HCC Expression View

Gene name : PTGS2
Ensembl ID ENSG00000073756
Description Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Source:Uniprot/SWISSPROT;Acc:P35354]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 1 up and 26 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 1 from 179907546 bp to 189916178 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 147050 -- IMAGE clone locate on exon ( tblastx )
845477 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.91) HK1 (-1.16) HK3 (-0.44) HK4 (-2.72) HK5 (0.00) HK7 (0.00) HK9 (-0.39) HK11 (-0.05) HK12 (-1.41) HK13 (-2.05) HK14 (-0.90) HK15 (-1.78) HK16 (-0.71) HK18 (-1.89) HK19 (-3.60) HK20 (-1.26) HK21 (0.75) HK22 (-0.23) HK24 (-2.28) HK27 (0.49) HK28 (-1.92) HK29 (-2.54) HK31 (-1.33) HK33 (-0.81) HK36 (-0.35) HK37 (-0.65) HK38 (-0.93) HK39 (-0.51) HK42 (-3.14) HK46 (-2.32) HK47 (-2.04) HK49 (-0.51) HK62 (-0.45) HK63 (-3.09) HK64 (-2.58) HK67 (0.46) HK84 (-1.08) HK85 (-4.36) SF1 (-1.84) SF12 (0.21) SF15 (-0.40) SF17 (0.00) SF18 (0.00) SF21 (0.01) SF22 (3.09) SF23 (-3.15) SF32 (-1.68) SF34 (-0.99) SF35 (-0.67) SF3 (-1.48) SF30 (-0.49) HK2 (-0.58) HK23 (0.48) HK41 (-2.49) SF4 (-2.47) SF8 (-0.53) SF9 (0.67)