OncoDB.HCC Expression View

Gene name : SLC4A4
Ensembl ID ENSG00000080493
Description Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1). [Source:Uniprot/SWISSPROT;Acc:Q9Y6R1]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
80 percent with 2 folds change ( 6 up and 36 down in 52 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 4 from 67271867 bp to 77656663 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 282104 -- IMAGE clone locate on exon ( tblastx )
787938 -- IMAGE clone locate on exon ( tblastx )
CH2 (-6.72) HK1 (-2.14) HK3 (-2.15) HK4 (-4.39) HK5 (-1.91) HK7 (0.00) HK9 (-5.58) HK11 (-1.81) HK12 (-1.35) HK13 (-1.10) HK14 (-1.83) HK15 (-1.75) HK16 (-0.24) HK18 (-2.16) HK19 (-0.88) HK20 (-2.91) HK21 (-1.42) HK22 (-0.30) HK24 (-3.05) HK27 (-3.60) HK28 (-1.89) HK29 (-1.41) HK31 (1.71) HK33 (0.01) HK36 (-2.35) HK37 (1.40) HK38 (-2.72) HK39 (-1.49) HK42 (1.64) HK46 (-0.76) HK47 (0.00) HK49 (-2.83) HK62 (-1.68) HK63 (-2.82) HK64 (-3.04) HK67 (-3.23) HK84 (0.00) HK85 (-0.96) SF1 (-1.68) SF12 (-2.26) SF15 (-1.54) SF17 (1.43) SF18 (0.00) SF21 (0.70) SF22 (-0.09) SF23 (0.18) SF32 (2.49) SF34 (0.00) SF35 (-1.78) SF3 (-1.79) SF30 (-0.81) HK2 (-3.94) HK23 (-1.41) HK41 (4.75) SF4 (-1.62) SF8 (-1.36) SF9 (-1.68)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).