OncoDB.HCC Expression View

Gene name : CXCL2
Ensembl ID ENSG00000081041
Description Macrophage inflammatory protein 2-alpha precursor (MIP2-alpha) (CXCL2) (Growth-regulated protein beta) (Gro-beta) [Contains: GRO-beta(5-73) (GRO-beta-T) (SB-251353) (Hematopoietic synergistic factor) (HSF)]. [Source:Uniprot/SWISSPROT;Acc:P19875]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
68 percent with 2 folds change ( 2 up and 37 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA microarray - - Shirota et al., Hepatology 33:832 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 4 from 70181657 bp to 80183874 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 323238 -- IMAGE clone locate on exon ( blastn )
324437 -- IMAGE clone locate on exon ( blastn )
153340 -- IMAGE clone locate on exon ( tblastx )
CH2 (-5.95) HK1 (-1.84) HK3 (-1.92) HK4 (-7.40) HK5 (-1.61) HK7 (-2.38) HK9 (-0.93) HK11 (-1.54) HK12 (-1.19) HK13 (0.01) HK14 (-0.77) HK15 (-3.17) HK16 (-2.10) HK18 (-0.29) HK19 (-2.94) HK20 (-1.65) HK21 (-1.37) HK22 (0.14) HK24 (-0.08) HK27 (-0.95) HK28 (-1.60) HK29 (-0.11) HK31 (-0.79) HK33 (-2.01) HK36 (-1.65) HK37 (-4.78) HK38 (0.33) HK39 (-0.62) HK42 (-0.85) HK46 (-4.28) HK47 (-6.00) HK49 (-2.93) HK62 (0.17) HK63 (-1.43) HK64 (-4.32) HK67 (-2.71) HK84 (-3.51) HK85 (0.53) SF1 (-1.27) SF12 (-5.54) SF15 (-0.44) SF17 (-4.48) SF18 (-5.68) SF21 (-1.92) SF22 (1.47) SF23 (-1.68) SF32 (1.42) SF34 (0.16) SF35 (-1.14) SF3 (-0.73) SF30 (-1.82) HK2 (-3.31) HK23 (-1.68) HK41 (-1.67) SF4 (-1.82) SF8 (-0.52) SF9 (-1.27)