OncoDB.HCC Expression View

Gene name : AFP
Ensembl ID ENSG00000081051
Description Alpha-fetoprotein precursor (Alpha-fetoglobulin) (Alpha-1- fetoprotein). [Source:Uniprot/SWISSPROT;Acc:P02771]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
74 percent with 2 folds change ( 20 up and 21 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 4 from 69520797 bp to 79540356 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 74537 -- IMAGE clone locate on exon ( blastn )
CH2 (0.00) HK1 (-0.40) HK3 (9.86) HK4 (-6.69) HK5 (-12.63) HK7 (-1.97) HK9 (13.72) HK11 (-7.35) HK12 (7.35) HK13 (-5.49) HK14 (-4.32) HK15 (11.66) HK16 (1.22) HK18 (0.23) HK19 (-3.69) HK20 (7.73) HK21 (13.15) HK22 (0.00) HK24 (1.15) HK27 (-0.94) HK28 (-0.51) HK29 (1.93) HK31 (-1.04) HK33 (-11.88) HK36 (-1.65) HK37 (4.50) HK38 (-11.99) HK39 (-12.87) HK42 (-4.52) HK46 (-0.10) HK47 (10.44) HK49 (1.90) HK62 (-9.17) HK63 (-6.64) HK64 (-0.79) HK67 (4.29) HK84 (5.52) HK85 (-2.95) SF1 (-5.76) SF12 (-0.89) SF15 (10.50) SF17 (-2.25) SF18 (10.17) SF21 (-0.86) SF22 (-2.36) SF23 (0.00) SF32 (3.94) SF34 (0.00) SF35 (0.50) SF3 (0.00) SF30 (-7.40) HK2 (13.38) HK23 (0.00) HK41 (-0.30) SF4 (-2.08) SF8 (9.95) SF9 (10.79)