OncoDB.HCC Expression View

Gene name : ABCB1
Ensembl ID ENSG00000085563
Description Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD243 antigen). [Source:Uniprot/SWISSPROT;Acc:P08183]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
31 percent with 2 folds change ( 3 up and 15 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC, RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 7 from 81970884 bp to 92180500 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 502721 -- IMAGE clone locate on exon ( tblastx )
813256 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.84) HK1 (-0.11) HK3 (0.25) HK4 (-0.27) HK5 (1.88) HK7 (-2.06) HK9 (-4.16) HK11 (-1.84) HK12 (-0.63) HK13 (0.08) HK14 (-1.96) HK15 (-0.97) HK16 (1.29) HK18 (-0.96) HK19 (-0.94) HK20 (-0.39) HK21 (-0.97) HK22 (-0.49) HK24 (0.85) HK27 (-0.79) HK28 (0.61) HK29 (0.92) HK31 (0.97) HK33 (1.21) HK36 (0.09) HK37 (-0.19) HK38 (-1.73) HK39 (-2.49) HK42 (-0.55) HK46 (0.64) HK47 (-3.26) HK49 (-0.46) HK62 (-0.89) HK63 (-0.09) HK64 (-0.20) HK67 (-0.80) HK84 (0.60) HK85 (0.07) SF1 (0.06) SF12 (-3.36) SF15 (-2.98) SF17 (0.72) SF18 (0.17) SF21 (0.03) SF22 (0.63) SF23 (-0.51) SF32 (0.28) SF34 (-1.73) SF35 (-1.53) SF3 (-1.18) SF30 (-2.38) HK2 (0.44) HK23 (-0.49) HK41 (-0.81) SF4 (-2.39) SF8 (0.16) SF9 (-0.63)