OncoDB.HCC Expression View

Gene name : MMP2
Ensembl ID ENSG00000087245
Description 72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1). [Source:Uniprot/SWISSPROT;Acc:P08253]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
62 percent with 2 folds change ( 11 up and 24 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up/down     Method -- IHC, ISH, RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene    
Display nearby genome region Chr 16 from 49070589 bp to 59098101 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1030498 -- IMAGE clone locate on exon ( tblastx )
1474174 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.92) HK1 (-1.33) HK3 (1.32) HK4 (-2.79) HK5 (0.02) HK7 (0.90) HK9 (-0.40) HK11 (2.52) HK12 (0.04) HK13 (-1.17) HK14 (-1.57) HK15 (2.07) HK16 (-1.03) HK18 (-1.06) HK19 (0.32) HK20 (-1.25) HK21 (1.50) HK22 (0.32) HK24 (0.39) HK27 (0.34) HK28 (-1.65) HK29 (-0.58) HK31 (-0.05) HK33 (-2.24) HK36 (-0.41) HK37 (-1.36) HK38 (-0.11) HK39 (1.74) HK42 (-1.16) HK46 (-2.45) HK47 (0.00) HK49 (1.16) HK62 (-0.34) HK63 (3.06) HK64 (-2.64) HK67 (-1.42) HK84 (-2.32) HK85 (-1.94) SF1 (-0.26) SF12 (-0.48) SF15 (-1.66) SF17 (-2.07) SF18 (1.33) SF21 (1.24) SF22 (1.46) SF23 (-2.55) SF32 (0.01) SF34 (-0.09) SF35 (4.42) SF3 (-3.18) SF30 (-1.34) HK2 (-1.86) HK23 (0.70) HK41 (-1.85) SF4 (0.09) SF8 (0.75) SF9 (-0.82)