OncoDB.HCC Expression View

Gene name : GNAS
Ensembl ID ENSG00000087460
Description Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas). [Source:Uniprot/SWISSPROT;Acc:Q5JWF2]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
21 percent with 2 folds change ( 10 up and 2 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- Western    
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Display nearby genome region Chr 20 from 51848168 bp to 61919642 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 359933 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.21) HK1 (-0.59) HK3 (0.48) HK4 (0.60) HK5 (0.00) HK7 (1.37) HK9 (-0.08) HK11 (1.08) HK12 (-0.57) HK13 (-0.25) HK14 (0.99) HK15 (-0.41) HK16 (-0.39) HK18 (-0.40) HK19 (-1.09) HK20 (0.77) HK21 (0.28) HK22 (-0.42) HK24 (0.47) HK27 (-0.19) HK28 (-0.23) HK29 (1.16) HK31 (0.59) HK33 (-0.36) HK36 (0.40) HK37 (-1.21) HK38 (0.00) HK39 (-0.13) HK42 (0.29) HK46 (-0.67) HK47 (0.96) HK49 (-0.07) HK62 (-0.42) HK63 (1.01) HK64 (0.06) HK67 (0.11) HK84 (0.75) HK85 (0.00) SF1 (1.43) SF12 (1.44) SF15 (-0.18) SF17 (1.62) SF18 (0.00) SF21 (1.42) SF22 (2.34) SF23 (-0.88) SF32 (0.47) SF34 (0.41) SF35 (0.21) SF3 (0.11) SF30 (0.68) HK2 (-0.55) HK23 (-0.35) HK41 (-0.88) SF4 (0.64) SF8 (-0.99) SF9 (0.63)