OncoDB.HCC Expression View

Gene name : AURKA
Ensembl ID ENSG00000087586
Description Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora kinase A) (Aurora-A) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Breast-tumor-amplified kinase). [Source:Uniprot/SWISSPROT;Acc:O14965]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
64 percent with 2 folds change ( 34 up and 2 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 20 from 49377852 bp to 59400758 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 129865 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-0.74) HK3 (2.78) HK4 (0.00) HK5 (1.18) HK7 (1.87) HK9 (3.38) HK11 (1.37) HK12 (1.36) HK13 (3.46) HK14 (1.84) HK15 (1.26) HK16 (1.36) HK18 (0.18) HK19 (2.47) HK20 (1.04) HK21 (0.39) HK22 (-6.25) HK24 (2.46) HK27 (0.68) HK28 (0.81) HK29 (2.44) HK31 (0.54) HK33 (-0.63) HK36 (1.34) HK37 (0.32) HK38 (3.27) HK39 (1.33) HK42 (2.65) HK46 (0.67) HK47 (-0.79) HK49 (0.54) HK62 (1.73) HK63 (3.60) HK64 (0.52) HK67 (-1.30) HK84 (2.46) HK85 (4.18) SF1 (1.52) SF12 (5.16) SF15 (2.73) SF17 (0.18) SF18 (0.00) SF21 (1.24) SF22 (6.09) SF23 (-0.22) SF32 (-0.00) SF34 (3.53) SF35 (1.84) SF3 (1.37) SF30 (2.41) HK2 (0.39) HK23 (0.26) HK41 (2.08) SF4 (1.50) SF8 (-0.58) SF9 (1.20)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).