OncoDB.HCC Expression View

Gene name : BIRC5
Ensembl ID ENSG00000089685
Description Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4). [Source:Uniprot/SWISSPROT;Acc:O15392]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
80 percent with 2 folds change ( 2 up and 42 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC, RT-PCR, QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene     COSMIC    
Display nearby genome region Chr 17 from 68721872 bp to 78733310 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 796694 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.73) HK1 (-2.56) HK3 (-3.03) HK4 (-3.02) HK5 (-2.67) HK7 (-2.21) HK9 (-2.84) HK11 (-3.13) HK12 (-1.70) HK13 (-2.28) HK14 (-1.20) HK15 (0.00) HK16 (-0.40) HK18 (-1.18) HK19 (-0.54) HK20 (-1.00) HK21 (-0.26) HK22 (-2.51) HK24 (-2.36) HK27 (-1.80) HK28 (-1.05) HK29 (1.75) HK31 (-5.40) HK33 (-4.13) HK36 (0.94) HK37 (-3.65) HK38 (-3.88) HK39 (-0.67) HK42 (-0.97) HK46 (-1.64) HK47 (-3.72) HK49 (-3.29) HK62 (1.24) HK63 (-0.33) HK64 (-2.49) HK67 (-4.61) HK84 (-2.99) HK85 (-0.61) SF1 (-1.84) SF12 (-2.37) SF15 (-1.81) SF17 (-1.40) SF18 (-3.29) SF21 (-0.29) SF22 (-2.02) SF23 (-0.28) SF32 (-2.94) SF34 (0.00) SF35 (-1.33) SF3 (-1.23) SF30 (-1.02) HK2 (-2.45) HK23 (-3.99) HK41 (-0.38) SF4 (-1.74) SF8 (-2.84) SF9 (-1.65)