OncoDB.HCC Expression View

Gene name : BLVRB
Ensembl ID ENSG00000090013
Description Flavin reductase (EC 1.5.1.30) (FR) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR) (Biliverdin reductase B) (EC 1.3.1.24) (BVR-B) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP). [Source:Uniprot/SWISSPROT;Acc:P30043]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
20 percent with 2 folds change ( 2 up and 9 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Iizuka et al., Oncogene 22:3007 (2003)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 19 from 40645541 bp to 50663435 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1420370 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.14) HK1 (-0.60) HK3 (-0.06) HK4 (-0.31) HK5 (0.45) HK7 (0.50) HK9 (-0.29) HK11 (-1.44) HK12 (-0.46) HK13 (-0.52) HK14 (-1.57) HK15 (0.13) HK16 (0.34) HK18 (-0.40) HK19 (0.00) HK20 (-0.12) HK21 (-1.19) HK22 (0.47) HK24 (0.73) HK27 (-0.41) HK28 (0.90) HK29 (0.63) HK31 (0.56) HK33 (-0.02) HK36 (0.00) HK37 (-0.75) HK38 (0.39) HK39 (-0.72) HK42 (-1.14) HK46 (0.24) HK47 (-1.77) HK49 (-2.41) HK62 (0.02) HK63 (-0.98) HK64 (-0.82) HK67 (-0.35) HK84 (0.54) HK85 (-1.30) SF1 (1.06) SF12 (-1.48) SF15 (-0.52) SF17 (-0.11) SF18 (-0.59) SF21 (-0.50) SF22 (-0.88) SF23 (0.52) SF32 (0.60) SF34 (0.69) SF35 (0.46) SF3 (0.00) SF30 (-0.53) HK2 (0.32) HK23 (1.08) HK41 (0.89) SF4 (0.86) SF8 (-0.10) SF9 (-0.77)