OncoDB.HCC Expression View

Gene name : ESR1
Ensembl ID ENSG00000091831
Description Estrogen receptor (ER) (Estradiol receptor) (ER-alpha). [Source:Uniprot/SWISSPROT;Acc:P03372]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
62 percent with 2 folds change ( 3 up and 29 down in 51 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- IHC, QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 6 from 147170379 bp to 157466099 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 594382 -- IMAGE clone locate on exon ( tblastx )
725321 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.85) HK1 (-1.12) HK3 (-1.19) HK4 (-4.18) HK5 (0.00) HK7 (-0.39) HK9 (-5.10) HK11 (-1.09) HK12 (-1.12) HK13 (-1.15) HK14 (-2.03) HK15 (-1.86) HK16 (0.05) HK18 (-1.25) HK19 (-0.55) HK20 (-0.60) HK21 (0.00) HK22 (-0.60) HK24 (-1.62) HK27 (-0.69) HK28 (-0.75) HK29 (-0.21) HK31 (-1.46) HK33 (-2.19) HK36 (-0.41) HK37 (-1.62) HK38 (0.77) HK39 (-0.70) HK42 (-0.59) HK46 (0.00) HK47 (-3.03) HK49 (-2.85) HK62 (1.05) HK63 (-2.55) HK64 (-2.35) HK67 (-0.62) HK84 (-0.43) HK85 (-1.52) SF1 (0.05) SF12 (0.00) SF15 (-4.05) SF17 (-0.20) SF18 (0.00) SF21 (1.48) SF22 (0.00) SF23 (1.22) SF32 (-1.43) SF34 (0.27) SF35 (0.52) SF3 (-3.45) SF30 (-1.05) HK2 (-2.22) HK23 (-3.38) HK41 (-0.94) SF4 (-2.20) SF8 (-2.21) SF9 (-6.25)