OncoDB.HCC Expression View

Gene name : COMT
Ensembl ID ENSG00000093010
Description Catechol O-methyltransferase (EC 2.1.1.6). [Source:Uniprot/SWISSPROT;Acc:P21964]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
10 percent with 2 folds change ( 0 up and 6 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Iizuka et al., Oncogene 22:3007 (2003)
down     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene    
Display nearby genome region Chr 22 from 13309334 bp to 23337450 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 773367 -- IMAGE clone locate on exon ( tblastx )
CH2 (-2.14) HK1 (-0.26) HK3 (0.32) HK4 (-0.59) HK5 (0.33) HK7 (0.65) HK9 (-0.91) HK11 (-0.32) HK12 (-0.21) HK13 (0.03) HK14 (-0.42) HK15 (-0.31) HK16 (-0.18) HK18 (0.12) HK19 (-0.11) HK20 (0.73) HK21 (-0.57) HK22 (-0.82) HK24 (-0.06) HK27 (-0.59) HK28 (0.21) HK29 (-0.10) HK31 (-0.63) HK33 (0.52) HK36 (0.39) HK37 (-0.85) HK38 (-0.94) HK39 (-0.04) HK42 (-0.59) HK46 (-0.49) HK47 (-0.99) HK49 (-0.53) HK62 (-0.38) HK63 (-0.35) HK64 (-0.21) HK67 (-0.08) HK84 (-0.12) HK85 (-0.65) SF1 (-0.40) SF12 (-1.96) SF15 (-0.58) SF17 (-1.35) SF18 (-1.35) SF21 (-2.21) SF22 (-1.70) SF23 (0.35) SF32 (0.60) SF34 (-0.22) SF35 (-0.92) SF3 (-0.64) SF30 (-0.45) HK2 (-0.40) HK23 (0.84) HK41 (0.00) SF4 (0.57) SF8 (0.44) SF9 (-0.12)