OncoDB.HCC Expression View

Gene name : CLIC1_HUMAN
Ensembl ID ENSG00000096238
Description Chloride intracellular channel protein 1 (Nuclear chloride ion channel 27) (NCC27) (Chloride channel ABP) (Regulatory nuclear chloride ion channel protein) (hRNCC). [Source:Uniprot/SWISSPROT;Acc:O00299]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
40 percent with 2 folds change ( 16 up and 6 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
Links Entrez Gene    
Display nearby genome region Chr c6_COX from 26833027 bp to 0 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 843121 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.71) HK1 (-0.22) HK3 (0.06) HK4 (0.87) HK5 (-0.34) HK7 (-0.37) HK9 (0.14) HK11 (1.21) HK12 (0.37) HK13 (0.43) HK14 (2.53) HK15 (1.00) HK16 (0.19) HK18 (0.69) HK19 (0.62) HK20 (-1.19) HK21 (1.42) HK22 (-1.07) HK24 (0.10) HK27 (1.40) HK28 (-0.96) HK29 (-0.91) HK31 (0.17) HK33 (0.29) HK36 (-0.27) HK37 (1.77) HK38 (1.06) HK39 (2.86) HK42 (1.25) HK46 (-1.03) HK47 (0.00) HK49 (1.34) HK62 (-0.36) HK63 (0.93) HK64 (-0.56) HK67 (0.52) HK84 (1.78) HK85 (1.06) SF1 (-0.14) SF12 (2.17) SF15 (-0.68) SF17 (-1.40) SF18 (0.43) SF21 (0.35) SF22 (0.99) SF23 (-0.88) SF32 (-0.62) SF34 (-0.61) SF35 (1.25) SF3 (0.67) SF30 (1.34) HK2 (0.86) HK23 (-1.10) HK41 (0.77) SF4 (0.49) SF8 (-1.51) SF9 (0.00)