OncoDB.HCC Expression View

Gene name : MTAP
Ensembl ID ENSG00000099810
Description S-methyl-5-thioadenosine phosphorylase (EC 2.4.2.28) (5'- methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAPase). [Source:Uniprot/SWISSPROT;Acc:Q13126]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
17 percent with 2 folds change ( 0 up and 3 down in 17 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 9 from 16792635 bp to 27022985 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 756734 -- IMAGE clone locate on exon ( blastn )
CH2 (0.00) HK1 (0.00) HK3 (0.00) HK4 (0.00) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (-0.12) HK12 (-0.03) HK13 (0.00) HK14 (-0.16) HK15 (0.00) HK16 (0.00) HK18 (-0.30) HK19 (0.04) HK20 (0.28) HK21 (-0.42) HK22 (-0.31) HK24 (0.48) HK27 (0.00) HK28 (0.00) HK29 (0.00) HK31 (0.00) HK33 (0.00) HK36 (0.00) HK37 (-1.52) HK38 (0.00) HK39 (0.00) HK42 (0.00) HK46 (-0.26) HK47 (0.00) HK49 (0.00) HK62 (0.00) HK63 (0.00) HK64 (-1.39) HK67 (0.00) HK84 (0.00) HK85 (0.00) SF1 (0.00) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (0.00) SF34 (-0.87) SF35 (0.00) SF3 (0.00) SF30 (-1.41) HK2 (0.00) HK23 (0.00) HK41 (0.00) SF4 (-0.57) SF8 (0.82) SF9 (-0.23)