OncoDB.HCC Expression View

Gene name : MMP11
Ensembl ID ENSG00000099953
Description Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11). [Source:Uniprot/SWISSPROT;Acc:P24347]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
23 percent with 2 folds change ( 7 up and 2 down in 39 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 22 from 17445036 bp to 27456502 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 487296 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (0.95) HK3 (0.48) HK4 (0.00) HK5 (0.00) HK7 (0.00) HK9 (0.16) HK11 (0.27) HK12 (1.41) HK13 (0.00) HK14 (0.56) HK15 (0.78) HK16 (0.00) HK18 (0.57) HK19 (0.54) HK20 (0.30) HK21 (1.53) HK22 (-0.33) HK24 (0.86) HK27 (0.58) HK28 (-0.49) HK29 (0.00) HK31 (0.12) HK33 (2.49) HK36 (-0.03) HK37 (-0.23) HK38 (0.36) HK39 (0.40) HK42 (0.80) HK46 (1.73) HK47 (-1.67) HK49 (-1.15) HK62 (0.00) HK63 (0.55) HK64 (0.00) HK67 (0.00) HK84 (-0.28) HK85 (0.00) SF1 (0.00) SF12 (0.00) SF15 (0.29) SF17 (0.27) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (0.15) SF34 (0.14) SF35 (1.55) SF3 (0.00) SF30 (1.66) HK2 (0.10) HK23 (0.29) HK41 (0.00) SF4 (1.14) SF8 (0.82) SF9 (0.87)