OncoDB.HCC Expression View

Gene name : MAPK1
Ensembl ID ENSG00000100030
Description Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1). [Source:Uniprot/SWISSPROT;Acc:P28482]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
10 percent with 2 folds change ( 6 up and 0 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 22 from 15446873 bp to 25551730 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 323506 -- IMAGE clone locate on exon ( blastn )
CH2 (1.09) HK1 (-0.15) HK3 (0.25) HK4 (-0.15) HK5 (-0.32) HK7 (0.51) HK9 (0.02) HK11 (0.32) HK12 (-0.11) HK13 (0.72) HK14 (0.53) HK15 (0.17) HK16 (-0.07) HK18 (0.14) HK19 (0.22) HK20 (0.15) HK21 (0.16) HK22 (0.13) HK24 (0.70) HK27 (-0.29) HK28 (-0.19) HK29 (0.04) HK31 (0.11) HK33 (-0.01) HK36 (0.65) HK37 (0.66) HK38 (0.20) HK39 (0.13) HK42 (-0.43) HK46 (0.18) HK47 (0.76) HK49 (1.21) HK62 (-0.36) HK63 (0.07) HK64 (0.30) HK67 (0.31) HK84 (0.51) HK85 (-0.65) SF1 (-0.63) SF12 (1.63) SF15 (0.19) SF17 (0.80) SF18 (0.74) SF21 (0.97) SF22 (0.98) SF23 (-0.13) SF32 (0.02) SF34 (-0.55) SF35 (-0.09) SF3 (0.22) SF30 (0.01) HK2 (1.15) HK23 (-0.53) HK41 (1.34) SF4 (0.87) SF8 (0.86) SF9 (1.15)