OncoDB.HCC Expression View

Gene name : MTHFD1
Ensembl ID ENSG00000100714
Description C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]. [Source:Uniprot/SWISSPROT;Acc:P11586]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
52 percent with 2 folds change ( 3 up and 27 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     cDNA Microarray - - Delpuech et al., Oncogene 21:2926 (2002)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Li et al., Mol Cell Proteomics 3:399 (2004)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene    
Display nearby genome region Chr 14 from 58924821 bp to 68996474 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 856535 -- IMAGE clone locate on exon ( blastn )
47384 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.68) HK1 (-1.17) HK3 (-0.47) HK4 (0.72) HK5 (-1.15) HK7 (0.92) HK9 (0.23) HK11 (-2.90) HK12 (-1.86) HK13 (0.56) HK14 (-2.07) HK15 (-1.68) HK16 (-1.85) HK18 (-1.41) HK19 (-1.77) HK20 (0.57) HK21 (-1.65) HK22 (-0.28) HK24 (-1.55) HK27 (-2.55) HK28 (-0.67) HK29 (-0.67) HK31 (-0.70) HK33 (-0.87) HK36 (1.34) HK37 (-0.22) HK38 (-1.50) HK39 (-1.09) HK42 (-1.37) HK46 (0.11) HK47 (-2.82) HK49 (-1.19) HK62 (-1.14) HK63 (-1.89) HK64 (0.78) HK67 (-0.02) HK84 (-1.27) HK85 (-1.43) SF1 (-1.18) SF12 (0.24) SF15 (1.47) SF17 (3.59) SF18 (-0.35) SF21 (0.63) SF22 (0.85) SF23 (0.43) SF32 (0.14) SF34 (-1.48) SF35 (-2.72) SF3 (-1.76) SF30 (-2.24) HK2 (-0.16) HK23 (-0.91) HK41 (-0.81) SF4 (0.39) SF8 (0.26) SF9 (-2.42)