OncoDB.HCC Expression View

Gene name : MMP9
Ensembl ID ENSG00000100985
Description Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]. [Source:Uniprot/SWISSPROT;Acc:P14780]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
36 percent with 2 folds change ( 12 up and 2 down in 38 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC, RT-PCR, QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene    
Display nearby genome region Chr 20 from 39070954 bp to 49078607 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 22040 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (0.55) HK3 (1.70) HK4 (-0.17) HK5 (0.00) HK7 (0.00) HK9 (-1.23) HK11 (2.27) HK12 (-0.33) HK13 (0.76) HK14 (2.33) HK15 (0.58) HK16 (0.00) HK18 (0.00) HK19 (0.00) HK20 (0.00) HK21 (0.43) HK22 (0.00) HK24 (0.94) HK27 (3.45) HK28 (-0.61) HK29 (-0.17) HK31 (-0.18) HK33 (-0.45) HK36 (-1.25) HK37 (0.34) HK38 (0.00) HK39 (1.19) HK42 (0.00) HK46 (-0.16) HK47 (-0.09) HK49 (1.55) HK62 (2.15) HK63 (-0.38) HK64 (0.69) HK67 (-0.28) HK84 (0.00) HK85 (-0.09) SF1 (0.86) SF12 (0.00) SF15 (0.11) SF17 (0.00) SF18 (0.00) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (0.09) SF34 (0.00) SF35 (1.14) SF3 (1.41) SF30 (2.18) HK2 (0.00) HK23 (0.86) HK41 (-0.03) SF4 (1.88) SF8 (0.46) SF9 (2.15)