OncoDB.HCC Expression View

Gene name : E2F1
Ensembl ID ENSG00000101412
Description Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1). [Source:Uniprot/SWISSPROT;Acc:Q01094]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
67 percent with 2 folds change ( 36 up and 2 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 20 from 26727147 bp to 36737871 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 236142 -- IMAGE clone locate on exon ( tblastx )
768260 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (1.31) HK3 (3.07) HK4 (1.19) HK5 (1.48) HK7 (3.13) HK9 (3.72) HK11 (0.35) HK12 (1.74) HK13 (4.89) HK14 (3.20) HK15 (1.54) HK16 (2.18) HK18 (-0.02) HK19 (1.58) HK20 (2.57) HK21 (0.05) HK22 (0.00) HK24 (2.28) HK27 (2.11) HK28 (0.97) HK29 (4.67) HK31 (2.60) HK33 (1.28) HK36 (-0.51) HK37 (2.15) HK38 (3.13) HK39 (2.80) HK42 (3.16) HK46 (1.38) HK47 (-2.13) HK49 (0.91) HK62 (5.41) HK63 (5.62) HK64 (1.18) HK67 (0.54) HK84 (3.70) HK85 (4.12) SF1 (0.85) SF12 (0.00) SF15 (-0.24) SF17 (2.44) SF18 (0.00) SF21 (2.87) SF22 (-2.65) SF23 (0.26) SF32 (1.44) SF34 (2.95) SF35 (4.98) SF3 (0.88) SF30 (3.29) HK2 (0.97) HK23 (-0.09) HK41 (2.42) SF4 (0.00) SF8 (0.70) SF9 (2.10)