OncoDB.HCC Expression View

Gene name : USP14
Ensembl ID ENSG00000101557
Description Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.1.2.15) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Deubiquitinating enzyme 14). [Source:Uniprot/SWISSPROT;Acc:P54578]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
15 percent with 2 folds change ( 7 up and 0 down in 44 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 18 from 0 bp to 5203739 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 81599 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.65) HK1 (0.59) HK3 (0.79) HK4 (1.11) HK5 (0.00) HK7 (0.00) HK9 (0.00) HK11 (0.95) HK12 (0.94) HK13 (0.07) HK14 (0.76) HK15 (0.48) HK16 (1.41) HK18 (1.35) HK19 (0.32) HK20 (0.28) HK21 (1.02) HK22 (0.33) HK24 (0.78) HK27 (0.43) HK28 (-0.05) HK29 (-0.54) HK31 (0.46) HK33 (0.49) HK36 (0.13) HK37 (1.17) HK38 (0.40) HK39 (0.07) HK42 (0.39) HK46 (0.00) HK47 (-0.01) HK49 (0.72) HK62 (-0.14) HK63 (0.38) HK64 (1.02) HK67 (-0.64) HK84 (0.00) HK85 (-0.40) SF1 (0.53) SF12 (0.00) SF15 (0.00) SF17 (0.00) SF18 (-0.09) SF21 (0.00) SF22 (0.00) SF23 (0.00) SF32 (0.32) SF34 (-0.76) SF35 (0.61) SF3 (1.02) SF30 (0.12) HK2 (0.28) HK23 (0.00) HK41 (0.58) SF4 (0.09) SF8 (0.00) SF9 (0.95)