OncoDB.HCC Expression View

Gene name : MAPK3
Ensembl ID ENSG00000102882
Description Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase). [Source:Uniprot/SWISSPROT;Acc:P27361]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
9 percent with 2 folds change ( 4 up and 1 down in 55 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 16 from 25032951 bp to 35042116 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 809939 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.39) HK1 (-0.27) HK3 (0.09) HK4 (0.47) HK5 (0.69) HK7 (0.00) HK9 (0.80) HK11 (1.18) HK12 (0.23) HK13 (-0.49) HK14 (0.59) HK15 (0.79) HK16 (0.39) HK18 (0.21) HK19 (-0.62) HK20 (0.16) HK21 (0.90) HK22 (-0.23) HK24 (0.52) HK27 (0.75) HK28 (0.75) HK29 (0.39) HK31 (0.79) HK33 (0.20) HK36 (-0.43) HK37 (-0.18) HK38 (-0.05) HK39 (0.99) HK42 (-0.61) HK46 (0.55) HK47 (0.01) HK49 (-0.17) HK62 (-0.20) HK63 (0.49) HK64 (-0.22) HK67 (-0.71) HK84 (0.15) HK85 (-0.74) SF1 (1.63) SF12 (0.46) SF15 (-1.36) SF17 (-0.41) SF18 (0.00) SF21 (1.48) SF22 (5.06) SF23 (-0.09) SF32 (0.66) SF34 (-0.06) SF35 (0.81) SF3 (0.24) SF30 (0.39) HK2 (0.00) HK23 (-0.23) HK41 (-0.95) SF4 (0.62) SF8 (0.27) SF9 (0.64)