OncoDB.HCC Expression View

Gene name : FAH
Ensembl ID ENSG00000103876
Description Fumarylacetoacetase (EC 3.7.1.2) (Fumarylacetoacetate hydrolase) (Beta-diketonase) (FAA). [Source:Uniprot/SWISSPROT;Acc:P16930]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
24 percent with 2 folds change ( 1 up and 13 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Kim et al., Clin Cancer Research 9:5493 (2003)
down     Proteomic Analysis - - Liang et al., Proteomics 5:2258 (2005)
Links Entrez Gene    
Display nearby genome region Chr 15 from 73232191 bp to 83265740 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 183200 -- IMAGE clone locate on exon ( blastn )
357626 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.88) HK1 (-0.56) HK3 (-0.60) HK4 (-2.29) HK5 (-0.06) HK7 (-1.99) HK9 (0.04) HK11 (-1.39) HK12 (-0.61) HK13 (-0.23) HK14 (-1.24) HK15 (-0.79) HK16 (-0.70) HK18 (0.15) HK19 (-0.11) HK20 (-0.01) HK21 (-1.53) HK22 (0.57) HK24 (-0.53) HK27 (-1.02) HK28 (-0.67) HK29 (-0.54) HK31 (-0.56) HK33 (0.10) HK36 (-0.89) HK37 (-0.57) HK38 (-0.46) HK39 (-1.61) HK42 (-0.81) HK46 (-0.73) HK47 (-1.58) HK49 (-1.12) HK62 (-0.08) HK63 (-0.25) HK64 (-0.97) HK67 (-0.39) HK84 (-1.17) HK85 (-0.70) SF1 (0.82) SF12 (-0.70) SF15 (-0.80) SF17 (0.39) SF18 (-0.10) SF21 (-0.43) SF22 (1.48) SF23 (-0.62) SF32 (0.89) SF34 (0.62) SF35 (-0.39) SF3 (-1.06) SF30 (-1.46) HK2 (-0.16) HK23 (0.14) HK41 (-0.07) SF4 (0.24) SF8 (-0.64) SF9 (-1.65)