OncoDB.HCC Expression View

Gene name : CA2
Ensembl ID ENSG00000104267
Description Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonic anhydrase II) (Carbonate dehydratase II) (CA-II) (Carbonic anhydrase C). [Source:Uniprot/SWISSPROT;Acc:P00918]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
56 percent with 2 folds change ( 7 up and 22 down in 51 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 8 from 81563433 bp to 91580945 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 51865 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.01) HK1 (-0.59) HK3 (-0.05) HK4 (-1.63) HK5 (-0.88) HK7 (-2.67) HK9 (0.00) HK11 (-0.71) HK12 (-1.64) HK13 (-1.06) HK14 (-0.79) HK15 (-2.05) HK16 (1.30) HK18 (-0.42) HK19 (-0.93) HK20 (-1.54) HK21 (-2.39) HK22 (-0.47) HK24 (0.29) HK27 (-1.94) HK28 (-0.88) HK29 (0.19) HK31 (0.27) HK33 (0.98) HK36 (0.44) HK37 (-3.96) HK38 (-0.63) HK39 (-2.87) HK42 (1.61) HK46 (-1.93) HK47 (-4.12) HK49 (0.58) HK62 (-2.56) HK63 (0.00) HK64 (-3.42) HK67 (0.00) HK84 (-2.57) HK85 (0.96) SF1 (1.42) SF12 (0.00) SF15 (-5.91) SF17 (2.06) SF18 (-3.53) SF21 (2.60) SF22 (0.00) SF23 (0.00) SF32 (2.70) SF34 (-0.49) SF35 (-0.85) SF3 (-0.49) SF30 (-1.81) HK2 (-1.17) HK23 (-1.68) HK41 (2.08) SF4 (-0.65) SF8 (-0.58) SF9 (-4.11)