OncoDB.HCC Expression View

Gene name : EIF3S6
Ensembl ID ENSG00000104408
Description Eukaryotic translation initiation factor 3 subunit 6 (eIF-3 p48) (eIF3e) (Viral integration site protein INT-6 homolog). [Source:Uniprot/SWISSPROT;Acc:P60228]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
42 percent with 2 folds change ( 22 up and 2 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Xu et al., Cancer Res. 61:3176 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 8 from 104283162 bp to 114330170 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 42452 -- IMAGE clone locate on exon ( tblastx )
856961 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.35) HK1 (1.43) HK3 (2.10) HK4 (1.99) HK5 (1.09) HK7 (-0.03) HK9 (0.04) HK11 (1.72) HK12 (-0.44) HK13 (1.06) HK14 (0.36) HK15 (-0.27) HK16 (-0.55) HK18 (2.44) HK19 (-0.12) HK20 (-1.12) HK21 (0.70) HK22 (0.60) HK24 (0.58) HK27 (1.71) HK28 (-0.01) HK29 (-0.64) HK31 (-0.34) HK33 (1.12) HK36 (0.64) HK37 (1.87) HK38 (1.19) HK39 (0.02) HK42 (-0.59) HK46 (1.42) HK47 (4.19) HK49 (0.89) HK62 (-0.08) HK63 (-0.43) HK64 (-0.44) HK67 (1.57) HK84 (2.36) HK85 (0.04) SF1 (1.78) SF12 (1.36) SF15 (3.14) SF17 (-0.29) SF18 (0.63) SF21 (-1.27) SF22 (-0.05) SF23 (-0.33) SF32 (-0.19) SF34 (-0.05) SF35 (0.12) SF3 (0.33) SF30 (1.09) HK2 (0.85) HK23 (0.90) HK41 (2.34) SF4 (-0.20) SF8 (0.30) SF9 (2.14)