OncoDB.HCC Expression View

Gene name : FGL1
Ensembl ID ENSG00000104760
Description Fibrinogen-like protein 1 precursor (Hepatocyte-derived fibrinogen- related protein 1) (HFREP-1) (Hepassocin) (HP-041). [Source:Uniprot/SWISSPROT;Acc:Q08830]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
35 percent with 2 folds change ( 7 up and 13 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
down     Proteomic Analysis - - Blanc et al., Proteomics 5:37788 (2005)
Links Entrez Gene     Entrez Gene    
Display nearby genome region Chr 8 from 12766169 bp to 22797693 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 129024 -- IMAGE clone locate on exon ( tblastx )
454771 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.26) HK1 (-0.16) HK3 (-2.37) HK4 (0.42) HK5 (0.64) HK7 (-1.82) HK9 (-0.21) HK11 (0.55) HK12 (-0.75) HK13 (1.10) HK14 (-0.28) HK15 (-1.70) HK16 (-0.32) HK18 (-0.44) HK19 (0.51) HK20 (-0.57) HK21 (-0.39) HK22 (2.73) HK24 (-0.11) HK27 (-0.07) HK28 (-0.19) HK29 (-0.28) HK31 (-1.10) HK33 (-4.29) HK36 (0.26) HK37 (0.42) HK38 (2.34) HK39 (-0.78) HK42 (-1.88) HK46 (0.50) HK47 (2.71) HK49 (1.05) HK62 (-0.58) HK63 (-2.11) HK64 (-2.31) HK67 (-1.22) HK84 (-0.33) HK85 (0.46) SF1 (0.82) SF12 (-0.72) SF15 (2.04) SF17 (-2.01) SF18 (0.24) SF21 (-0.95) SF22 (1.21) SF23 (-0.73) SF32 (-0.09) SF34 (0.35) SF35 (-1.31) SF3 (-0.70) SF30 (0.77) HK2 (-1.40) HK23 (-3.39) HK41 (0.37) SF4 (-0.05) SF8 (-0.31) SF9 (-0.84)