OncoDB.HCC Expression View

Gene name : AKT2
Ensembl ID ENSG00000105221
Description RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta). [Source:Uniprot/SWISSPROT;Acc:P31751]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
19 percent with 2 folds change ( 6 up and 4 down in 51 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 19 from 40430084 bp to 50483036 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 810420 -- IMAGE clone locate on exon ( tblastx )
CH2 (2.52) HK1 (-0.13) HK3 (-0.09) HK4 (-1.43) HK5 (0.29) HK7 (2.17) HK9 (0.28) HK11 (-2.00) HK12 (-0.18) HK13 (0.62) HK14 (1.14) HK15 (-0.28) HK16 (0.02) HK18 (-0.08) HK19 (-0.31) HK20 (0.61) HK21 (-0.42) HK22 (-0.49) HK24 (-0.63) HK27 (-0.96) HK28 (-0.29) HK29 (0.86) HK31 (0.00) HK33 (-0.53) HK36 (1.08) HK37 (0.00) HK38 (-0.80) HK39 (0.14) HK42 (0.00) HK46 (-0.09) HK47 (-0.69) HK49 (-0.19) HK62 (0.13) HK63 (-0.35) HK64 (0.95) HK67 (0.34) HK84 (0.00) HK85 (0.00) SF1 (-0.20) SF12 (2.18) SF15 (0.75) SF17 (1.96) SF18 (0.00) SF21 (0.93) SF22 (-1.03) SF23 (-0.85) SF32 (-0.28) SF34 (-0.07) SF35 (-1.26) SF3 (-0.52) SF30 (-0.27) HK2 (0.63) HK23 (-0.63) HK41 (-0.33) SF4 (-0.09) SF8 (-0.07) SF9 (-0.23)