OncoDB.HCC Expression View

Gene name : HAMP
Ensembl ID ENSG00000105697
Description Hepcidin precursor (Liver-expressed antimicrobial peptide) (LEAP-1) (Putative liver tumor regressor) (PLTR) [Contains: Hepcidin-25 (Hepc25); Hepcidin-20 (Hepc20)]. [Source:Uniprot/SWISSPROT;Acc:P81172]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
83 percent with 2 folds change ( 1 up and 44 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
down     PCR Array - - Kurokawa et al., J Hepatol. 39:1004 (2003)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 19 from 35465250 bp to 45467886 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 74054 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-5.17) HK3 (-4.64) HK4 (-6.38) HK5 (-6.23) HK7 (-7.84) HK9 (-5.45) HK11 (-4.48) HK12 (-5.03) HK13 (-0.80) HK14 (-6.80) HK15 (-2.98) HK16 (-3.79) HK18 (-5.20) HK19 (-5.37) HK20 (-5.34) HK21 (-0.67) HK22 (-0.43) HK24 (-5.49) HK27 (-5.25) HK28 (-0.62) HK29 (-1.01) HK31 (-6.54) HK33 (-5.29) HK36 (-3.44) HK37 (-8.31) HK38 (-0.31) HK39 (-5.15) HK42 (-3.89) HK46 (-6.70) HK47 (-4.86) HK49 (-6.79) HK62 (-0.59) HK63 (0.00) HK64 (-9.53) HK67 (-2.75) HK84 (-5.71) HK85 (-5.09) SF1 (-2.87) SF12 (-7.20) SF15 (2.92) SF17 (-5.98) SF18 (-6.37) SF21 (0.00) SF22 (-0.24) SF23 (0.94) SF32 (-3.33) SF34 (-3.84) SF35 (-4.35) SF3 (-2.63) SF30 (-5.97) HK2 (-5.83) HK23 (-3.01) HK41 (-5.95) SF4 (-5.69) SF8 (-2.91) SF9 (0.34)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).