OncoDB.HCC Expression View

Gene name : MET
Ensembl ID ENSG00000105976
Description Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met). [Source:Uniprot/SWISSPROT;Acc:P08581]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
26 percent with 2 folds change ( 11 up and 4 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, Mutation    
>> Link to terminologies used in OncoDB.HCC
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 7 from 111099695 bp to 121223632 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 915737 -- IMAGE clone locate on exon ( blastn )
626841 -- IMAGE clone locate on exon ( tblastx )
754509 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (-0.10) HK3 (0.24) HK4 (0.16) HK5 (-0.32) HK7 (-0.17) HK9 (0.45) HK11 (0.55) HK12 (0.41) HK13 (0.41) HK14 (0.07) HK15 (0.27) HK16 (0.59) HK18 (-0.23) HK19 (0.01) HK20 (0.78) HK21 (0.25) HK22 (-0.09) HK24 (0.65) HK27 (-1.60) HK28 (0.62) HK29 (0.87) HK31 (1.02) HK33 (1.38) HK36 (0.04) HK37 (0.95) HK38 (0.62) HK39 (-2.07) HK42 (-1.06) HK46 (0.66) HK47 (0.29) HK49 (1.22) HK62 (-0.84) HK63 (0.33) HK64 (1.68) HK67 (-0.62) HK84 (1.57) HK85 (1.45) SF1 (0.17) SF12 (2.52) SF15 (-0.65) SF17 (2.35) SF18 (0.41) SF21 (-0.43) SF22 (-0.53) SF23 (0.50) SF32 (1.11) SF34 (-0.93) SF35 (-1.46) SF3 (0.51) SF30 (-0.05) HK2 (0.96) HK23 (1.31) HK41 (2.17) SF4 (-0.50) SF8 (0.22) SF9 (0.79)