OncoDB.HCC Expression View

Gene name : HSPB1
Ensembl ID ENSG00000106211
Description Heat-shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDa protein) (28 kDa heat shock protein). [Source:Uniprot/SWISSPROT;Acc:P04792]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
20 percent with 2 folds change ( 7 up and 4 down in 54 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- IHC    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
up     Affy. Microarray - - Iizuka et al., J Cancer Res Clin Oncol 132:473 (2006)
up     Proteomic Analysis - - Li et al., Proteomics 5:1125 (2005)
Links Entrez Gene    
Display nearby genome region Chr 7 from 70769966 bp to 80771545 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 1056316 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.00) HK1 (0.30) HK3 (0.73) HK4 (-1.19) HK5 (0.55) HK7 (0.14) HK9 (0.07) HK11 (-1.28) HK12 (-0.24) HK13 (-1.05) HK14 (-0.16) HK15 (-0.29) HK16 (0.28) HK18 (0.04) HK19 (-0.02) HK20 (-0.65) HK21 (-0.50) HK22 (-1.00) HK24 (-0.03) HK27 (0.52) HK28 (0.31) HK29 (0.87) HK31 (-0.77) HK33 (1.59) HK36 (1.87) HK37 (0.28) HK38 (-0.60) HK39 (-0.27) HK42 (0.08) HK46 (0.18) HK47 (-1.27) HK49 (-0.46) HK62 (0.15) HK63 (0.08) HK64 (-0.25) HK67 (-0.47) HK84 (0.35) HK85 (-0.28) SF1 (0.00) SF12 (-0.65) SF15 (0.00) SF17 (1.23) SF18 (1.50) SF21 (1.08) SF22 (1.66) SF23 (2.06) SF32 (-0.99) SF34 (0.15) SF35 (0.07) SF3 (0.40) SF30 (0.52) HK2 (0.00) HK23 (0.02) HK41 (0.71) SF4 (-0.03) SF8 (-0.26) SF9 (-0.17)