OncoDB.HCC Expression View

Gene name : SERPINE1
Ensembl ID ENSG00000106366
Description Plasminogen activator inhibitor 1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI). [Source:Uniprot/SWISSPROT;Acc:P05121]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
65 percent with 2 folds change ( 1 up and 33 down in 52 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence down     Method -- QPCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     COSMIC    
Display nearby genome region Chr 7 from 95557172 bp to 105569026 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 244307 -- IMAGE clone locate on exon ( tblastx )
CH2 (-3.37) HK1 (-0.87) HK3 (-2.44) HK4 (-2.41) HK5 (-2.67) HK7 (-1.17) HK9 (-1.95) HK11 (-0.91) HK12 (0.39) HK13 (0.00) HK14 (0.04) HK15 (0.07) HK16 (-0.57) HK18 (-1.89) HK19 (0.40) HK20 (-3.65) HK21 (1.31) HK22 (-1.56) HK24 (-2.07) HK27 (-0.27) HK28 (-1.73) HK29 (-1.42) HK31 (-2.57) HK33 (0.00) HK36 (0.00) HK37 (0.84) HK38 (-1.53) HK39 (-0.09) HK42 (-1.77) HK46 (-1.69) HK47 (-2.16) HK49 (0.57) HK62 (-1.94) HK63 (-1.26) HK64 (-2.69) HK67 (-1.62) HK84 (-2.74) HK85 (-2.71) SF1 (-0.96) SF12 (0.97) SF15 (-3.34) SF17 (0.00) SF18 (-1.69) SF21 (-2.09) SF22 (-2.92) SF23 (0.19) SF32 (-2.45) SF34 (-1.55) SF35 (0.00) SF3 (0.58) SF30 (-0.42) HK2 (-3.42) HK23 (-2.09) HK41 (-1.56) SF4 (-1.12) SF8 (0.29) SF9 (0.07)