OncoDB.HCC Expression View

Gene name : TRDMT1
Ensembl ID ENSG00000107614
Description tRNA (cytosine-5-)-methyltransferase (EC 2.1.1.29) (DNA (cytosine-5)- methyltransferase-like protein 2) (Dnmt2) (DNA methyltransferase homolog HsaIIP) (DNA MTase homolog HsaIIP) (M.HsaIIP) (PuMet). [Source:Uniprot/SWISSPROT;Acc:O14717]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
55 percent with 2 folds change ( 1 up and 30 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene     Entrez Gene     Entrez Gene    
Display nearby genome region Chr 10 from 12224851 bp to 22283665 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 198982 -- IMAGE clone locate on exon ( tblastx )
CH2 (-1.68) HK1 (-1.68) HK3 (0.37) HK4 (-0.14) HK5 (-1.87) HK7 (-0.72) HK9 (-1.75) HK11 (0.00) HK12 (-0.89) HK13 (0.69) HK14 (-2.07) HK15 (-1.31) HK16 (0.31) HK18 (-0.71) HK19 (-0.91) HK20 (-0.42) HK21 (-2.27) HK22 (-0.17) HK24 (-0.81) HK27 (-2.49) HK28 (1.03) HK29 (-1.10) HK31 (-1.56) HK33 (0.06) HK36 (-1.96) HK37 (-0.84) HK38 (-3.20) HK39 (-2.96) HK42 (-0.97) HK46 (-1.23) HK47 (-0.61) HK49 (-0.60) HK62 (-1.23) HK63 (-1.72) HK64 (-0.13) HK67 (-0.90) HK84 (-2.35) HK85 (-1.44) SF1 (-1.76) SF12 (-2.31) SF15 (-2.55) SF17 (-1.00) SF18 (-2.46) SF21 (0.48) SF22 (-2.66) SF23 (0.26) SF32 (-0.49) SF34 (-0.46) SF35 (-1.97) SF3 (-2.19) SF30 (-2.81) HK2 (0.06) HK23 (0.38) HK41 (-1.30) SF4 (-1.46) SF8 (0.13) SF9 (-3.72)