OncoDB.HCC Expression View

Gene name : DKK1
Ensembl ID ENSG00000107984
Description Dickkopf-related protein 1 precursor (Dkk-1) (Dickkopf-1) (hDkk-1) (SK). [Source:Uniprot/SWISSPROT;Acc:O94907]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
81 percent with 2 folds change ( 27 up and 16 down in 53 paired-arrays )
With wet-lab experimental data from previous reports.
Links Entrez Gene    
Display nearby genome region Chr 10 from 48744064 bp to 58747595 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 669375 -- IMAGE clone locate on exon ( tblastx )
CH2 (-7.00) HK1 (2.87) HK3 (8.02) HK4 (0.00) HK5 (2.49) HK7 (0.10) HK9 (1.50) HK11 (2.23) HK12 (1.72) HK13 (-1.93) HK14 (4.07) HK15 (6.24) HK16 (-0.91) HK18 (-0.21) HK19 (1.42) HK20 (7.05) HK21 (6.89) HK22 (-1.53) HK24 (1.95) HK27 (1.58) HK28 (-4.58) HK29 (-7.41) HK31 (1.25) HK33 (3.21) HK36 (4.59) HK37 (1.52) HK38 (-2.61) HK39 (1.65) HK42 (0.00) HK46 (5.37) HK47 (0.00) HK49 (0.00) HK62 (-7.46) HK63 (-13.09) HK64 (6.85) HK67 (-0.46) HK84 (0.00) HK85 (-1.35) SF1 (0.80) SF12 (-5.70) SF15 (-3.67) SF17 (1.10) SF18 (0.00) SF21 (-8.58) SF22 (-4.30) SF23 (-1.74) SF32 (1.04) SF34 (-8.50) SF35 (-7.45) SF3 (0.00) SF30 (2.33) HK2 (2.33) HK23 (10.20) HK41 (0.00) SF4 (0.84) SF8 (2.01) SF9 (6.25)

Experimental Validation

The semi-quantitative RT-PCR results performed by OncoDB.HCC in 45 HCC pairs are presented in gel images (left), in quantified expression profiles after normalization with ]-actin expression as an internal control (right).