OncoDB.HCC Expression View

Gene name : CBX1
Ensembl ID ENSG00000108468
Description Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) (HP1Hsbeta) (p25beta). [Source:Uniprot/SWISSPROT;Acc:P83916]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
33 percent with 2 folds change ( 17 up and 2 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Reference expression data
up     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
up     cDNA Microarray - - Neo et al., Hepatology 39:944 (2004)
up     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 17 from 38502414 bp to 48533806 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 786084 -- IMAGE clone locate on exon ( tblastx )
CH2 (1.28) HK1 (0.25) HK3 (1.04) HK4 (0.69) HK5 (0.06) HK7 (0.76) HK9 (1.61) HK11 (0.77) HK12 (0.31) HK13 (-1.27) HK14 (1.73) HK15 (-0.15) HK16 (-0.15) HK18 (0.28) HK19 (0.82) HK20 (0.17) HK21 (1.36) HK22 (0.67) HK24 (0.95) HK27 (1.16) HK28 (1.04) HK29 (0.22) HK31 (0.28) HK33 (0.66) HK36 (0.62) HK37 (1.14) HK38 (0.65) HK39 (0.88) HK42 (2.20) HK46 (0.04) HK47 (0.74) HK49 (0.46) HK62 (-1.12) HK63 (1.53) HK64 (1.80) HK67 (-0.12) HK84 (1.04) HK85 (0.72) SF1 (1.41) SF12 (0.76) SF15 (-0.05) SF17 (-0.02) SF18 (0.65) SF21 (0.52) SF22 (1.01) SF23 (-0.47) SF32 (-0.40) SF34 (0.13) SF35 (1.72) SF3 (0.70) SF30 (1.97) HK2 (0.54) HK23 (-0.26) HK41 (0.60) SF4 (-0.19) SF8 (0.15) SF9 (1.66)