OncoDB.HCC Expression View

Gene name : VTN
Ensembl ID ENSG00000109072
Description Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B]. [Source:Uniprot/SWISSPROT;Acc:P04004]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
42 percent with 2 folds change ( 12 up and 12 down in 57 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- Northern    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Honda et al., Gastroenterology 120:955(2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 17 from 18718425 bp to 28721844 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 246073 -- IMAGE clone locate on exon ( tblastx )
247546 -- IMAGE clone locate on exon ( tblastx )
CH2 (-0.32) HK1 (-0.62) HK3 (-1.83) HK4 (1.09) HK5 (-1.46) HK7 (-0.47) HK9 (-0.22) HK11 (1.76) HK12 (0.06) HK13 (1.00) HK14 (0.06) HK15 (-1.53) HK16 (0.62) HK18 (-0.92) HK19 (0.53) HK20 (-1.62) HK21 (-1.22) HK22 (1.97) HK24 (0.64) HK27 (-0.38) HK28 (1.02) HK29 (-1.00) HK31 (-0.32) HK33 (0.49) HK36 (0.86) HK37 (-1.35) HK38 (1.94) HK39 (-0.57) HK42 (-0.26) HK46 (0.26) HK47 (-1.09) HK49 (4.79) HK62 (-1.41) HK63 (1.41) HK64 (-0.33) HK67 (0.06) HK84 (0.45) HK85 (2.56) SF1 (0.20) SF12 (-0.31) SF15 (-0.16) SF17 (0.88) SF18 (-1.02) SF21 (0.37) SF22 (2.76) SF23 (-0.21) SF32 (-0.68) SF34 (1.72) SF35 (-0.25) SF3 (-0.16) SF30 (3.91) HK2 (-0.91) HK23 (-2.07) HK41 (-1.48) SF4 (0.62) SF8 (-1.11) SF9 (0.53)