OncoDB.HCC Expression View

Gene name : CCND1
Ensembl ID ENSG00000110092
Description G1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene). [Source:Uniprot/SWISSPROT;Acc:P24385]
HCC significant gene
Significantly up- or down- regulated in at least three independent HCC microarray/proteomic reports.
At least 2 folds expression change in more than 70% patients in reprocessed Stanford HCC microarray data.
50 percent with 2 folds change ( 2 up and 26 down in 56 paired-arrays )
With wet-lab experimental data from previous reports.
Experimental evidence up     Method -- RT-PCR, IHC, Western    
>> Link to terminologies used in OncoDB.HCC
Reference expression data
down     cDNA Microarray - - Okabe et al., Cancer Res. 61:2129 (2001)
down     EST and cDNA Microarray - - Xu et al., PNAS 98:15089 (2001)
down     Stanford Microarray - - Chen et al., Mol Biol Cell. 13:1929 (2002)
Links Entrez Gene    
Display nearby genome region Chr 11 from 64165054 bp to 74178422 bp

Standford microarray data
Re-analysis of Stanford microarray data
IMAGE clone 113856 -- IMAGE clone locate on exon ( blastn )
841641 -- IMAGE clone locate on exon ( tblastx )
CH2 (0.97) HK1 (0.52) HK3 (-2.35) HK4 (-0.47) HK5 (0.75) HK7 (-2.66) HK9 (0.99) HK11 (-0.73) HK12 (0.42) HK13 (-2.51) HK14 (-3.22) HK15 (-1.00) HK16 (0.47) HK18 (-1.63) HK19 (1.03) HK20 (-2.78) HK21 (-0.37) HK22 (-1.13) HK24 (-0.26) HK27 (-1.23) HK28 (-0.28) HK29 (0.08) HK31 (-2.15) HK33 (-0.48) HK36 (-0.25) HK37 (0.68) HK38 (-1.73) HK39 (-2.31) HK42 (-2.13) HK46 (0.01) HK47 (-2.26) HK49 (-1.15) HK62 (-2.13) HK63 (-3.01) HK64 (-2.42) HK67 (-0.48) HK84 (-1.45) HK85 (-0.65) SF1 (-2.46) SF12 (-1.78) SF15 (-0.79) SF17 (-1.00) SF18 (-1.93) SF21 (0.00) SF22 (-1.69) SF23 (1.58) SF32 (0.32) SF34 (0.14) SF35 (-0.57) SF3 (-1.42) SF30 (-2.91) HK2 (-0.03) HK23 (-0.60) HK41 (-1.59) SF4 (-1.42) SF8 (0.69) SF9 (-0.99)